![]() Shoe size: 15/17 - 18/19 - 20/21 - 22/23 (24/25 - 26/28)ĭROPS FABEL from Garnstudio (belongs to yarn group A)ĥ0-50-50-50 (50-50) g colour 922, fruit patchĭROPS CIRCULAR NEEDLE SIZE 2.5 MM – length 80 cm.Ģ6 stitches in width and 48 rows in height with garter stitch = 10 x 10 cm. Hence our results provide new insight to the quantitative evaluation of methylation status of the human genome and can act as an alternative to PCR with a great potential.ĭNA methylation Fiber optic biosensor Gastric cancer Gold nanoparticle Localized surface plasmon resonance SOCS-1.Ĭopyright © 2022 Elsevier B.V. In addition, our data were significantly correlated to the data obtained from PCR-based pyrosequencing, and yet with superior accuracy. The observed detection limit is 0.81 fM for methylated DNA, and the detection time is within 15 min. ![]() We designed a specific DNA probe fabricated on the fiber core surface while the other probe is bioconjugated with gold nanoparticles in free form to allow percentage determination and differentiating the methylated and unmethylated cell lines, further demonstrating the SOCS-1 methylation occurs in cancer patients but not in normal cell lines. The method is based on the fiber optic nanogold-linked sorbent assay of PCR-free DNA from human gastric tumor tissue and cell lines. ![]() We have developed an amplification-free fiber optic nanoplasmonic biosensor for detecting DNA methylation of the SOCS-1 human genome. Electronic address: new innovative approach is essential for early and effective diagnosis of gastric cancer, using promoter hypermethylation of the tumor suppressor, SOCS-1, that is frequently inactivated in human cancers. Electronic address: 9 Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan. Electronic address: 8 Department of Biomedical Sciences, National Chung Cheng University, Chiayi, Taiwan Center for Nano Bio-Detection, National Chung Cheng University, Chiayi, Taiwan Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, Chiayi, Taiwan Epigenomics and Human Disease Research Center, National Chung Cheng University, Chiayi, Taiwan. 7 Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi, Taiwan Center for Nano Bio-Detection, National Chung Cheng University, Chiayi, Taiwan Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, Chiayi, Taiwan.Electronic address: 1 Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi, Taiwan. ![]() 6 Department of Chemical and Materials Engineering, NCU-Covestro Research Center, National Central University, Taoyuan, Taiwan R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan, Taiwan.5 Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi, Taiwan School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan Center for Nano Bio-Detection, National Chung Cheng University, Chiayi, Taiwan.4 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.3 Department of Biomedical Sciences, National Chung Cheng University, Chiayi, Taiwan.2 Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan College of Medicine, National Chung Hsiung University, Taichung, Taiwan.1 Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi, Taiwan.
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